Disease Knowledge Center

Evidence-Based Medical Encyclopedia

Explore thousands of diseases with authoritative clinical information from WHO, CDC, NIH, and international medical guidelines. Every condition features an interactive journey from diagnosis to treatment.

200 Diseases
60 Specialties
276 Sources

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Featured Conditions

Gastroenterology K22.0

Achalasia

Achalasia is an esophageal motility disorder caused by nerve degeneration, resulting in failure of the lower esophageal sphincter to relax and progressive difficulty swallowing.

Endocrinology E22.0

Acromegaly

Acromegaly is a hormonal disorder caused by a pituitary tumor producing too much growth hormone, leading to enlarged hands, feet, and facial features.

Cardiology I24.9

Acute Coronary Syndrome

Acute Coronary Syndrome is a heart attack or severe angina caused by a sudden blockage in a coronary artery, cutting off blood and oxygen to the heart muscle.

Dermatology L70.0

Acne Vulgaris

Acne vulgaris is a common inflammatory skin condition caused by blocked hair follicles and oil glands, leading to pimples, blackheads, and cysts.

Hematology & Oncology

Acute Lymphoblastic Leukemia

A rapid-onset blood cancer where immature white blood cells (lymphoblasts) multiply uncontrollably in the bone marrow, crowding out healthy cells.

Nephrology N17.9

Acute Kidney Injury

Acute Kidney Injury is a sudden loss of kidney function, often due to decreased blood flow, toxins, or blockages, leading to a dangerous buildup of waste and fluids.

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Gastroenterology

Acute Cholecystitis

Acute inflammation of the gallbladder, mostly due to gallstone obstruction of the cystic duct, causing severe right upper quadrant pain.

Gastroenterology K85.9

Acute Pancreatitis

Acute pancreatitis is a sudden and extremely painful inflammation of the pancreas, most often caused by gallstones or heavy alcohol use, where the organ begins to digest itself.

Oncology & Gastroenterology

Hepatocellular Carcinoma

The primary cancer of the liver, almost always arising in cirrhotic patients, diagnosed via dynamic imaging and treated by resection, ablation, or transplant.

Neurology G50.0

Trigeminal Neuralgia

A nerve disorder causing sudden, severe, electric shock-like pain in the face, often triggered by simple actions like brushing teeth or chewing.

Cardiology I50.9

Congestive Heart Failure

A chronic, progressive condition where the heart cannot pump efficiently, causing fluid to back up into the lungs and body.

General Surgery

Appendicitis

A sudden inflammation of the appendix, often caused by a blockage, resulting in severe right lower belly pain and requiring surgical removal.

Neurology G30.9

Alzheimer Disease

A fatal neurodegenerative disease defined by amyloid plaques and tau tangles, causing progressive memory loss, cognitive decline, and eventual loss of independent function.

Infectious Diseases & Cardiology B57.2

Chagas Disease

A parasitic infection transmitted by 'kissing bugs' in the Americas, which can lie dormant for decades before causing heart failure and enlarged digestive organs.

Otolaryngology

Meniere Disease

An inner ear disorder causing sudden attacks of spinning dizziness, ringing in the ear, and progressive hearing loss due to fluid buildup.

Infectious Diseases

Hepatitis C Virus Infection

A curable viral liver disease transmitted via blood that causes silent liver damage, cirrhosis, and cancer over decades.

Dermatology L40.0

Psoriasis Vulgaris

A chronic autoimmune skin disease causing red, scaly plaques on extensor surfaces, driven by overactive T-cells and rapid skin cell turnover.

Infectious Diseases & Dermatology

Leprosy

A chronic bacterial infection of the skin and nerves caused by M. leprae, leading to numb skin patches and potential limb deformities if untreated.

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