Disease Knowledge Center

Evidence-Based Medical Encyclopedia

Explore thousands of diseases with authoritative clinical information from WHO, CDC, NIH, and international medical guidelines. Every condition features an interactive journey from diagnosis to treatment.

200 Diseases
60 Specialties
276 Sources

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Featured Conditions

Gastroenterology K22.0

Achalasia

Achalasia is an esophageal motility disorder caused by nerve degeneration, resulting in failure of the lower esophageal sphincter to relax and progressive difficulty swallowing.

Endocrinology E22.0

Acromegaly

Acromegaly is a hormonal disorder caused by a pituitary tumor producing too much growth hormone, leading to enlarged hands, feet, and facial features.

Cardiology I24.9

Acute Coronary Syndrome

Acute Coronary Syndrome is a heart attack or severe angina caused by a sudden blockage in a coronary artery, cutting off blood and oxygen to the heart muscle.

Dermatology L70.0

Acne Vulgaris

Acne vulgaris is a common inflammatory skin condition caused by blocked hair follicles and oil glands, leading to pimples, blackheads, and cysts.

Hematology & Oncology

Acute Lymphoblastic Leukemia

A rapid-onset blood cancer where immature white blood cells (lymphoblasts) multiply uncontrollably in the bone marrow, crowding out healthy cells.

Nephrology N17.9

Acute Kidney Injury

Acute Kidney Injury is a sudden loss of kidney function, often due to decreased blood flow, toxins, or blockages, leading to a dangerous buildup of waste and fluids.

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Hematology & Gastroenterology

Pernicious Anemia

An autoimmune disease causing lack of intrinsic factor, preventing Vitamin B12 absorption, and resulting in severe anemia and progressive nerve damage.

Oncology

Multiple Myeloma

A blood cancer involving malignant plasma cells in the bone marrow that causes bone destruction, kidney failure, anemia, and hypercalcemia.

Gastroenterology

Liver Cirrhosis

Extensive scarring of the liver caused by long-term damage, leading to liver failure, portal hypertension, and severe systemic complications.

Gastroenterology K27.9

Peptic Ulcer Disease

A disruption of the gastric or duodenal mucosa primarily caused by H. pylori infection or NSAID use, presenting with dyspepsia and epigastric pain.

Endocrinology E24.9

Cushing Syndrome

A hormonal disorder caused by prolonged exposure to inappropriately high levels of cortisol.

Cardiology I10

Essential Hypertension

Chronic high blood pressure with no single clear cause, significantly increasing the risk of heart attacks and strokes.

Pulmonology I26.99

Pulmonary Embolism

A life-threatening blood clot in the lungs that blocks blood flow, causing sudden shortness of breath and chest pain.

Neurology & Endocrinology

Hashimoto Encephalopathy

A rare, steroid-responsive encephalopathy presenting with altered mental status and seizures, associated with elevated anti-TPO/anti-Tg antibodies but unrelated to actual thyroid function.

Infectious Diseases

Malaria

A mosquito-borne parasitic disease causing cyclical fevers, chills, and severe anemia, with the falciparum species being potentially fatal.

Nephrology

Chronic Kidney Disease

Irreversible, progressive decline in kidney function occurring over months to years.

Dermatology & Pediatrics

Molluscum Contagiosum

A viral skin infection causing small, firm, pearly bumps with a dimple in the center, most common in children.

Rheumatology & Nephrology

Granulomatosis with Polyangiitis

A life-threatening systemic vasculitis driven by PR3-ANCA, causing necrotizing granulomas in the upper/lower respiratory tract and rapidly progressive glomerulonephritis.

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